Globulin calculator (total protein minus albumin)
The proteins in your blood other than albumin, including antibodies. Most reports calculate it as total protein minus albumin. Type your results in the units on your report and it works out Globulin as you type, in your browser.
AI-verified against cited sources. Awaiting expert reviewLast reviewed 2026-10-03Liver
Type your results above, or fill in the example, to see Globulin.
Nothing you type here leaves your browser.
Educational information, not medical advice. Blood Test Tracker doesn’t diagnose or treat, and it doesn’t replace your clinician. Talk with your clinician before changing medications, supplements or care.
How it’s worked out
The formula
Globulin (g/dL) = Total protein (g/dL) − Albumin (g/dL). In SI units, Globulin (g/L) = Total protein (g/L) − Albumin (g/L).
When the equation works
Outside these limits the calculator says so instead of giving a number.
- Albumin has to be lower than total protein.
A worked example
Example numbers, not anyone’s real results, run through the same code as the calculator above.
| Total Protein | 7 g/dL |
|---|---|
| Albumin | 4.3 g/dL |
| Globulin | 2.7 g/dL |
For an adult, this result is in the usual range.
What Globulin tells you
Globulins are a mixed group of proteins in your blood. Some help carry nutrients, some help your blood clot, and the gamma globulins are antibodies that help fight infection. Your liver and your immune system make them. On a standard panel, globulin is not measured on its own: the lab subtracts albumin from total protein. Because the result lumps every non-albumin protein together, a protein electrophoresis test is used when a clinician wants to see which ones changed.
Globulin gives a rough picture of inflammation and the immune system. A high level is often linked to long-lasting inflammation or infection, and a low level can mean the body is making fewer antibodies or losing protein. It is also half of the albumin-to-globulin (A/G) ratio. A single number cannot show the cause, so your clinician reads it with albumin, your other results and how you feel. Results just outside the range are common and often have simple explanations.
Read the full page on Globulin, with what a high or low result can mean.
Usual ranges
The ranges the result above is placed on. Your own lab’s printed range comes first if it gives one.
- 18+1.5–4.5 g/dL
Sources: Labcorp, Cleveland Clinic
Sources
The equation
- LOINC 10834-0: Globulin [Mass/volume] in Serum by calculation, NLM Clinical Tables Search Service (LOINC)
- Total Protein Test, Lab Tests Online UK (Association for Laboratory Medicine)
4 more sources for the ranges and the explanation
- Comprehensive Metabolic Panel (14) (test 322000), Labcorp
- Sample report, Comprehensive Metabolic Panel (14) (test 322000), Labcorp
- Globulin Blood Test, Cleveland Clinic (2022)
- Total Protein and Albumin/Globulin (A/G) Ratio, MedlinePlus (National Library of Medicine)
AI-verified against cited sources. Awaiting expert review. Last reviewed 2026-10-03. The calculator is version 1.0.0 of our code for this equation, tested against published examples. How we build and check these pages.