Skip to content
Blood Test Tracker

Extractable Nuclear Antigen (ENA) Panel

Specific nuclear antibodies for lupus, Sjogren, scleroderma and myositis.

7 tests explainedAlso printed as ENA Panel, ENA Screen, ENA 6, Extractable Nuclear Antibodies

Check your whole panel

Type the results from your report. Each one is placed on its usual range, with its status in words.

Type the results from your Extractable Nuclear Antigen (ENA) Panel report. Each one is placed on its usual range as you type.

  • AU/mL
  • AU/mL
  • AU/mL
  • AU/mL
  • AI

Nothing you type here leaves your browser. Ranges differ a little between labs, so the range on your own report is the one your result is judged against.

The 7 tests in this panel

What each one measures and the range labs usually print for adults. Ranges differ a little between labs, so the range on your own report is the one your result is judged against.

  • ENA Screen (extractable nuclear antigens)

    Looks for antibodies to several proteins inside the cell nucleus at once; a positive screen is followed by tests that name the exact antibody.

  • Anti-Smith (Sm) Antibody

    Looks for antibodies to the Smith (Sm) protein. A positive result is uncommon and is most closely linked with lupus.

    Adults
    0–40 AU/mL

  • Anti-U1-RNP Antibody (RNP)

    Looks for antibodies to U1-RNP. They are most closely linked with mixed connective tissue disease and can also appear in lupus and related conditions.

  • Anti-SSA/Ro Antibody

    Looks for antibodies to the Ro (SSA) protein. They are common in Sjögren's disease and lupus, and they matter for pregnancy planning.

    Adults
    0–40 AU/mL

  • Anti-SSB/La Antibody

    Looks for antibodies to La (SSB), which often appear together with anti-Ro. They are linked to Sjögren's disease and lupus and matter for pregnancy planning.

    Adults
    0–40 AU/mL

  • Anti-Scl-70 (Topoisomerase I) Antibody

    Antibodies against an enzyme called topoisomerase I. A positive result is linked to systemic sclerosis (scleroderma), especially the diffuse form of the disease.

    Adults
    0–29 AU/mL

  • Anti-Centromere B (CENP-B) Antibody

    Measures antibodies against CENP-B, a protein at the center of chromosomes. They are linked to limited systemic sclerosis (CREST) and, in some people, to primary biliary cholangitis.

    Adults
    0–1 AI

Labs can include 3 more tests in this panel that we haven’t written up yet.