{"id":"psa-total","name":"PSA, Total (Prostate-Specific Antigen)","shortName":"PSA","aliases":["Prostate Specific Ag","PSA, Total","Prostate Specific Antigen","Prostate-Specific Antigen (PSA)","PSA","Total PSA","PSA Total","PSA, Serum","PSA, Total, Serum","Prostate Specific Ag, Serum","Prostate-Specific Ag Diagnostic, S","PSA Total, Diagnostic","PSA Screen","Prostate-Specific Antigen, Total","Prostate Specific Antigen, Total","PSA, Ultrasensitive","Ultrasensitive PSA","Prostate-specific Antigen (PSA), Ultrasensitive","Antígeno prostático específico","Antígeno prostático específico total"],"abbreviations":["PSA","tPSA"],"loinc":[{"code":"2857-1","primary":true},{"code":"83112-3","primary":false},{"code":"35741-8","primary":false}],"specimen":"serum-or-plasma","units":[{"ucum":"ng/mL","display":"ng/mL"},{"ucum":"ug/L","display":"µg/L"}],"referenceRanges":[{"population":"Men","low":0,"high":4,"unit":"ng/mL","unitDisplay":"ng/mL","note":"The interval most US labs print for all adult men (Labcorp and ARUP both print 0–4.0 ng/mL). The AUA guideline says the 4.0 cutoff comes from very early studies of men thought to be free of prostate cancer, and that there is no universally accepted definition of an elevated PSA. No cutoff rules cancer out (Thompson 2004), and the number depends on the assay and its calibration: in one study, the same Beckman Access assay calibrated to the WHO standard read about 25% lower than with its traditional Hybritech calibration (Stephan 2008). Labcorp says this interval is not meant for follow-up after prostate cancer treatment.","sources":[{"title":"Prostate-Specific Antigen (PSA) (test 010322)","url":"https://www.labcorp.com/tests/010322/prostate-specific-antigen-psa","publisher":"Labcorp"},{"title":"Prostate-Specific Antigen (PSA), Ultrasensitive (test 140731)","url":"https://www.labcorp.com/test-menu/33776/prostate-specific-antigen-psa-ultrasensitive","publisher":"Labcorp"},{"title":"Prostate Specific Antigen, Total (test 0070121)","url":"https://ltd.aruplab.com/Tests/Pub/0070121","publisher":"ARUP Laboratories"},{"title":"Early Detection of Prostate Cancer: AUA/SUO Guideline (2023, amended 2026)","url":"https://www.auanet.org/documents/Guidelines/PDF/2026%20Guidelines/EDPC%202026%20Unabridged%20FINAL.pdf","publisher":"American Urological Association","year":2026},{"title":"Prostate-Specific Antigen (PSA) Test","url":"https://www.cancer.gov/types/prostate/psa-fact-sheet","publisher":"National Cancer Institute","year":2025},{"title":"Toward metrological traceability in the determination of prostate-specific antigen (PSA): calibrating Beckman Coulter Hybritech Access PSA assays to WHO standards compared with the traditional Hybritech standards","url":"https://pubmed.ncbi.nlm.nih.gov/18839463/","publisher":"Clinical Chemistry and Laboratory Medicine","year":2008},{"title":"Prevalence of prostate cancer among men with a prostate-specific antigen level <=4.0 ng per milliliter","url":"https://pubmed.ncbi.nlm.nih.gov/15163773/","publisher":"New England Journal of Medicine","year":2004}]},{"population":"Men, 40–49","low":0,"high":2.5,"unit":"ng/mL","unitDisplay":"ng/mL","note":"Mayo Clinic Laboratories upper limits by decade of age (95th percentile; the limits include men with benign prostate enlargement and exclude men with proven cancer), run on the Roche Elecsys assay. The 40s to 70s limits match the original Oesterling 1993 study and the University of Iowa handbook. Use the most specific range that fits the person; the all-ages 0–4.0 row is the fallback.","sources":[{"title":"PSA - Overview: Prostate-Specific Antigen (PSA) Diagnostic, Serum","url":"https://www.mayocliniclabs.com/test-catalog/overview/9284","publisher":"Mayo Clinic Laboratories"},{"title":"Serum prostate-specific antigen in a community-based population of healthy men. Establishment of age-specific reference ranges","url":"https://pubmed.ncbi.nlm.nih.gov/7688054/","publisher":"JAMA","year":1993},{"title":"Prostate-Specific Antigen (PSA), Total","url":"https://www.healthcare.uiowa.edu/Path_Handbook/handbook/test1566.html","publisher":"University of Iowa Hospitals and Clinics Pathology Handbook"}]},{"population":"Men, 50–59","low":0,"high":3.5,"unit":"ng/mL","unitDisplay":"ng/mL","sources":[{"title":"PSA - Overview: Prostate-Specific Antigen (PSA) Diagnostic, Serum","url":"https://www.mayocliniclabs.com/test-catalog/overview/9284","publisher":"Mayo Clinic Laboratories"},{"title":"Serum prostate-specific antigen in a community-based population of healthy men. Establishment of age-specific reference ranges","url":"https://pubmed.ncbi.nlm.nih.gov/7688054/","publisher":"JAMA","year":1993},{"title":"Prostate-Specific Antigen (PSA), Total","url":"https://www.healthcare.uiowa.edu/Path_Handbook/handbook/test1566.html","publisher":"University of Iowa Hospitals and Clinics Pathology Handbook"}]},{"population":"Men, 60–69","low":0,"high":4.5,"unit":"ng/mL","unitDisplay":"ng/mL","sources":[{"title":"PSA - Overview: Prostate-Specific Antigen (PSA) Diagnostic, Serum","url":"https://www.mayocliniclabs.com/test-catalog/overview/9284","publisher":"Mayo Clinic Laboratories"},{"title":"Serum prostate-specific antigen in a community-based population of healthy men. Establishment of age-specific reference ranges","url":"https://pubmed.ncbi.nlm.nih.gov/7688054/","publisher":"JAMA","year":1993},{"title":"Prostate-Specific Antigen (PSA), Total","url":"https://www.healthcare.uiowa.edu/Path_Handbook/handbook/test1566.html","publisher":"University of Iowa Hospitals and Clinics Pathology Handbook"}]},{"population":"Men, 70–79","low":0,"high":6.5,"unit":"ng/mL","unitDisplay":"ng/mL","sources":[{"title":"PSA - Overview: Prostate-Specific Antigen (PSA) Diagnostic, Serum","url":"https://www.mayocliniclabs.com/test-catalog/overview/9284","publisher":"Mayo Clinic Laboratories"},{"title":"Serum prostate-specific antigen in a community-based population of healthy men. Establishment of age-specific reference ranges","url":"https://pubmed.ncbi.nlm.nih.gov/7688054/","publisher":"JAMA","year":1993},{"title":"Prostate-Specific Antigen (PSA), Total","url":"https://www.healthcare.uiowa.edu/Path_Handbook/handbook/test1566.html","publisher":"University of Iowa Hospitals and Clinics Pathology Handbook"}]},{"population":"Men, 80+","low":0,"high":7.2,"unit":"ng/mL","unitDisplay":"ng/mL","note":"Mayo Clinic Laboratories only; not part of the 1993 Oesterling data, which stopped at age 79.","sources":[{"title":"PSA - Overview: Prostate-Specific Antigen (PSA) Diagnostic, Serum","url":"https://www.mayocliniclabs.com/test-catalog/overview/9284","publisher":"Mayo Clinic Laboratories"}]}],"review":{"status":"ai-draft","label":"AI-drafted. Awaiting verification","lastReviewed":"2026-10-03"},"summary":"A protein made by the prostate gland. Blood levels rise with age, prostate enlargement, inflammation and sometimes prostate cancer.","url":"https://bloodtesttracker.com/markers/psa-total","notice":"Information, not medical advice. Ranges differ between labs, so the range on your own report is the one your result is judged against."}