{"id":"nt-probnp","name":"NT-proBNP (N-Terminal pro-B-Type Natriuretic Peptide)","shortName":"NT-proBNP","aliases":["N-Terminal pro-BNP","NT-pro BNP","NTproBNP","Pro-BNP","N-terminal pro-B-type natriuretic peptide","PROBNP, N TERMINAL","NT-pro B-type natriuretic peptide","NT-proBNP, Plasma","NT-proBNP, Serum","N-terminal prohormone brain natriuretic peptide"],"abbreviations":["NT-proBNP","NTproBNP","NT-BNP"],"loinc":[{"code":"33762-6","primary":true},{"code":"83107-3","primary":false},{"code":"33763-4","primary":false},{"code":"83108-1","primary":false}],"specimen":"serum-or-plasma","units":[{"ucum":"pg/mL","display":"pg/mL"},{"ucum":"ng/L","display":"ng/L"},{"ucum":"pmol/L","display":"pmol/L"}],"referenceRanges":[{"population":"18–74","low":null,"high":124.9,"unit":"pg/mL","unitDisplay":"pg/mL","note":"Under 125 pg/mL (same number as ng/L) is the usual cutoff for adults under 75. It is stored as 124.9 so that a result of exactly 125 falls outside. This is a rule-out cutoff for heart failure in people with symptoms, not the central 95% of healthy people: ESC and AHA recommend 125 pg/mL for non-acute (outpatient) testing, and healthy adults over 70 often have levels above it (AugUR study). Reference limits depend on the assay and lab, so check the range printed on your own report.","sources":[{"title":"B-Type Natriuretic Peptide (BNP) Test","url":"https://my.clevelandclinic.org/health/diagnostics/22629-b-type-natriuretic-peptide","publisher":"Cleveland Clinic"},{"title":"Guideline for the Use of Natriuretic Peptides in the Early Diagnosis and Management of Heart Failure in Primary Care (Joint Consensus Report by the Eurasian Society of Heart Failure and the Turkish Association of Family Medicine)","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11881534/","publisher":"Balkan Medical Journal","year":2025},{"title":"NT-proBNP in the very old population: reference values and heart failure specificity from the AugUR-study","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13457255/","publisher":"Clinical Research in Cardiology","year":2026}]},{"population":"75+","low":null,"high":449.9,"unit":"pg/mL","unitDisplay":"pg/mL","note":"Cleveland Clinic lists under 450 pg/mL for people over 75. It is stored as 449.9 so that a result of exactly 450 falls outside. This is a rule-out style limit, not a healthy-population 95% interval: in the AugUR study of cardiovascular-healthy adults aged 70 and older, the 97.5th percentile was roughly 540 to 940 pg/mL depending on age group and sex. Other labs print different age-banded limits (for example, UW Medicine prints 0 to 450 for ages 0 to 49, 0 to 900 for 50 to 74 and 0 to 1800 for 75 and older), so check the range printed on your own report.","sources":[{"title":"B-Type Natriuretic Peptide (BNP) Test","url":"https://my.clevelandclinic.org/health/diagnostics/22629-b-type-natriuretic-peptide","publisher":"Cleveland Clinic"},{"title":"NT-proBNP in the very old population: reference values and heart failure specificity from the AugUR-study","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13457255/","publisher":"Clinical Research in Cardiology","year":2026}]}],"review":{"status":"ai-verified","label":"AI-verified against cited sources. Awaiting expert review","lastReviewed":"2026-10-03"},"summary":"A protein fragment your heart releases when it is under strain. It helps clinicians judge whether symptoms like breathlessness could come from heart failure.","url":"https://bloodtesttracker.com/markers/nt-probnp","notice":"Information, not medical advice. Ranges differ between labs, so the range on your own report is the one your result is judged against."}