{"id":"ia-2-antibody","name":"IA-2 Antibody (Islet Antigen-2)","shortName":"IA-2 Ab","aliases":["IA-2 Antibody","Islet Antigen 2 Antibody","IA-2A","Tyrosine Phosphatase IA-2 Ab","ICA512 Antibody","Anti-IA-2","IA-2 Autoantibody","Islet Antigen-2 (IA-2) Autoantibody","Islet Antigen 2 Autoantibody","ICA-512","Islet Cell Antigen 512 Antibody","Anti-IA2 Antibody","IA2 Autoantibodies","IA-2 Ab","IA2 Antibody","Tyrosine Phosphatase-Like Protein Antibodies","Tyrosine Phosphatase-Related Islet Antigen 2 Antibody"],"abbreviations":["IA-2","IA-2A","IA2","ICA512"],"loinc":[{"code":"56718-0","primary":true},{"code":"31209-0","primary":false},{"code":"70253-0","primary":false}],"specimen":"serum","units":[{"ucum":"[arb'U]/mL","display":"U/mL"}],"referenceRanges":[{"population":"Adults","low":0,"high":7.4,"unit":"[arb'U]/mL","unitDisplay":"U/mL","note":"ARUP's ELISA reports 0.0 to 7.4 U/mL and calls 7.5 U/mL or more positive. The Esoterix assay listed in Mayo's catalog also uses less than 7.5 U/mL as negative, which matches the RSR ELISA kit threshold. Quest's ELISA, as listed by Mayo, uses a lower cutoff of less than 5.4 U/mL and says its range was set for that method. Units and cutoffs depend on the kit, so use the cutoff and flag printed on your own report.","sources":[{"title":"Islet Antigen-2 (IA-2) Autoantibody, Serum (ARUP test 3001499)","url":"https://ltd.aruplab.com/Tests/Pub/3001499","publisher":"ARUP Laboratories","year":2026},{"title":"IA2 Autoantibodies (Mayo Clinic Laboratories test FIAAB)","url":"https://www.testcatalog.org/show/FIAAB","publisher":"Mayo Clinic Laboratories (Extended Catalog mirror, testcatalog.org)","year":2026},{"title":"Diabetes Autoimmune Profile (Mayo Clinic Laboratories test FDAIP)","url":"https://www.testcatalog.org/show/FDAIP","publisher":"Mayo Clinic Laboratories (Extended Catalog mirror, testcatalog.org)","year":2026},{"title":"Comparison of IA-2 Bridge ELISA and Radiobinding Assays for Progression Risk Assessment in Early-Stage Type 1 Diabetes","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13071206/","publisher":"Diabetes, Obesity and Metabolism 2026;28:4409-4412","year":2026}]}],"review":{"status":"ai-verified","label":"AI-verified against cited sources. Awaiting expert review","lastReviewed":"2026-10-03"},"summary":"Measures antibodies to IA-2, a protein in insulin-making cells, which is one of the islet antibodies used to look for autoimmune (type 1) diabetes.","url":"https://bloodtesttracker.com/markers/ia-2-antibody","notice":"Information, not medical advice. Ranges differ between labs, so the range on your own report is the one your result is judged against."}